Cagrilintide
AM833, Cagri, CagriSema (with semaglutide)
Long-acting amylin analogue that works through a satiety pathway separate from GLP-1 - which is why it combines with incretins instead of duplicating them.
Human trials
Investigational. Studied mainly as CagriSema, a fixed combination with semaglutide, in Novo Nordisk's REDEFINE programme. Not approved.
What it is
Amylin is a hormone co-secreted with insulin by pancreatic beta cells. It signals satiety and slows gastric emptying through pathways in the hindbrain that are distinct from GLP-1 signalling. Cagrilintide is a long-acting synthetic amylin analogue engineered for weekly dosing.
Why it matters
The reason cagrilintide gets attention is combination, not monotherapy. Because it works on a different satiety pathway, adding it to semaglutide is genuinely additive rather than redundant - unlike stacking two incretins, which mostly stacks side effects.
CagriSema (cagrilintide + semaglutide) trials have reported weight reductions in the low-to-mid twenties percent at 68 weeks, putting the combination in retatrutide territory using two well-understood mechanisms instead of one novel triple agonist.
Practical notes
- Alone, cagrilintide produces meaningful but unremarkable weight loss. It is a combination drug in practice.
- Nausea is not additive in a friendly way. Running cagrilintide alongside a GLP-1 means two satiety mechanisms and two nausea sources; titration of the pair has to be slower than titration of either alone.
- Grey-market cagrilintide is common precisely because the approved combination does not exist yet, and it carries every sourcing problem described in safety and sourcing.
Side effects and warning signs
Commonly reported
- Nausea and vomiting, overlapping heavily with GLP-1 effects when combined
- Injection-site reactions
- Appetite suppression that compounds with any incretin taken alongside it
Stop and get medical help
- Persistent vomiting and inability to maintain fluid intake
- Severe abdominal pain
Sources
From the community
Discussion for this compound concentrates in r/Peptidesource and r/GLP1.
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